Spiroketals are cyclic ketals in which two rings are joined by a single spiro atom and two ketal oxygen flanking the spiro atom, each belonging to one of the rings. Spiroketals are structural subunits found in many biologically active natural products originated from a variety of sources including marine organisms, vegetable, insect, microbes, and fungal sources. The Spiroketals moiety is often a primary pharmacophore in molecules having wide range of pharmacological activities such as anti-biotic, antifungal, anti-HIV, or could also find applications in cancer therapy. The present review emphasizes on the various methods used to synthesize spiroketals and their pharmacological evaluation from year 1979 to 2012.
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